The Potential Role of Lipopeptide Biosurfactant Generated by Acinetobacter junii B6 on Leishmania Tropica: The Synergy of Lipopeptide Biosurfactant and Glucantime

An in vitro investigation was carried out to assess how the lipopeptide biosurfactant (LPB) produced by Acinetobacter junii B6 affects Leishmania tropica infection and associated cytokine gene expression macrophages infected with L. tropica. Glucantime® (meglumine antimoniate, MA) LPB were investigated for their leishmanicidal effect, alone combination (LPB + MA), using a colorimetric test macrophage model. Immunomodulatory impact also evaluated through analysis of Th1 Th2 after treatment MA LPB, individually combination. The MA/LPB showed higher inhibitory impacts on amastigotes promastigotes than each alone. Cytokine confirmed LPB’s affinity IFN-γ, affirming elevated IL-12p40 IFN- γ concentrations addition reduction secretion IL-10 dose-dependent manner, particularly combined treatment. results indicated effectiveness along parasite growth promoting immune reaction level, which may be considered as possible therapeutic strategy treat those anthroponotic cutaneous leishmaniasis.